The Bi-annual World AIDS conference in Washington next July announces its theme. "Turning The Tide Together" reflects a unique moment in time, emphasizing that the AIDS epidemic has reached a defining moment. By acting decisively on recent scientific advances in HIV treatment and biomedical prevention, the momentum for a cure, and the continuing evidence of the ability to scale-up key interventions in the most-needed settings, we now have the potential to change the course of HIV and AIDS.